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Rejuran Injectables -
Skin Bio-Regenerator

Rejuran® is the brand name of a new class of injectable treatments called 'polynucleotides'. It is currently the only TGA-approved polynucleotide product available in Australia. Unlike the brand names of anti-wrinkle or filler products, Rejuran is not classified as a medicines or an S4 drug as so it can be named explicitly on websites, social media and in marketing.

 

Polynucleotides are very different to facial volumisers, bio-remodellers or bio-stimulators. Rejuran is made from marine-derived DNA fragments - the so called polynucleotides. When injected, the DNA fragments signal to the dermis of your skin via a number of different cellular pathways. Essentially, they help support your skin's own regenerative capabilities. Polynucleotides can help promote healing, repair and rejuvenation. 

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Rejuran is a clear, colourless and odourless solution. It contains polynucleotides or 'PN' for short. The PN are sourced from wild salmon from the Pacific Ocean. Rejuran is manufactured in a plant in South Korea where the salmon are not farmed or bred. Instead the salmon migrate back to Korea from the USA and after mating, they naturally reach the end of their life cycle.

 

Polynucleotides are purified, bio-active DNA fragments. You can think of these as building blocks that when added together make up strands of DNA. Injectable polynucleotides are very runny liquids in appearance so they look and feel like a watery serum. Therefore they are completely different to other traditional injectable products such as facial volumisers.

 

Rejuran is injected as multiple tiny dots just under the surface of the skin known as the 'dermis'. So immediately after a treatment you will see multiple raised dots all over the skin. This 'bumpy' look to the skin lasts for approximately 48 hours

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When injected, polynucleotides help stimulate your body's own regenerative and repair mechanisms. Rejuran has been used in Asia since 2014 and over 10 million syringes have been used to date. A huge advantage of polynucleotides is that they do not cause vascular occlusions. This means the risk of blindness or stroke (that is associated with fillers) is essentially zero.

 

Korean doctors with nearly a decade of experience using Rejuran have noticed how it also seems help improve issues like sensitive skin and redness. It's therefore also a very useful product when used in combination with laser treatments to improve healing and downtime from these treatments, but also to optimise the overall results. Those who suffer with rosacea or melasma can therefore also consider adding Rejuran into their overall skin treatment plan as it can improve the health of the skin barrier (in combination with other treatments).

Key features of Rejuran treatments

Consultations

New patient consultation + Rejuran treatments = 45 mins.

​Existing patient consultations + treatments = 30 mins.

Skin quality improvement

Common areas to use Rejuran include the skin of the under eyes, forehead, rest of the face, neck and décolletage (upper chest). Improved texture, firmness, crepiness can be expected as well as improving inflammation or redness.

Safety

Rejuran treatments will be visible for approximately 48 hours. But since Rejuran isn't a filler, serious complications like vascular occlusions and blindness are not risks associated with it. 

How many treatments?

Initially 3 treatments are recommended, 2-4 weeks apart. This is followed by once every 3-6 months for maintenance.

Rejuran is injected as tiny dots all over the areas treated. Local anaesthetic cream will be applied prior and the injections associated with some very minor discomfort.

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Bruising is always possible with these tiny injections, especially around the eye area. Nurse Sarah recommends booking an LED treatment post-procedure to help accelerate the healing process but this isn't mandatory. Avoiding any blood thinners 7 days prior including fish oils, aspirin and NSAID medications is also strongly advised.

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As a result of how Rejuran is injected, you will have multiple visible bumps over the skin area treated. These are self-limiting and in normal skin will disperse on their own in approximately 48 hours. If you have thinner or peri-menopausal skin, this may take a day or so longer. So whilst you can go to work or socialise (and use make up the day after), you may feel self-conscious or have people asking what treatment you had done. So these treatments should be planned accordingly if you need to be discrete.

Downtime & aftercare for Rejuran treatments

You can go back to your normal daily activities after a treatment except for a few important instructions:

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1) Do not apply any makeup, bronzer, fake tan products, serums, sunscreen or similar for at least 12 hours after a treatment. It's vital to avoid any risk of infection.

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2) Do not massage or rub the areas injected until any tenderness has subsided. This also includes not doing treatments like having a facial, lying down on a table for a massage or similar. You should let any swelling subside before these. It's also best to avoid any significant heat including laser/radio-frequency treatments, saunas, hot yoga, etc.

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3) It's best to avoid doing any sports, exercise or vigorous activity for

24 - 48 hours afterwards. This will allow the initial swelling after to start improving and reduce your chances of any delayed bruising (as raising your blood pressure and core temperature significantly increase blood flow to the skin).

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What if I think I have a problem or need to be seen after my filler treatment?

Nurse Sarah offers complimentary 30 minute filler reviews for patients and this can be booked online yourself. If you're experiencing anything outside of what's listed above or you're simply not sure, please just email the clinic with some photos of the area treated 

Aftercare for Rejuran treatments

It is a new class of injectable called polynucleotides. These are made from marine-derived DNA and are non-hyaluronic acid based. This means that they are not classed as fillers and work completely differently to fillers.

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What exactly is Rejuran?

Polynucleotides are long chains of amino acids that are naturally found in your body. They are expressed in the skin where they play important roles in skin health. Injections are designed to provide cellular remodelling addressing:

• Collagen stimulation

• Slowing down the aging process

• Treatment of lines, wrinkles, pores & textural changes

• Hydration of skin (but bio-remodelling treatments are better if hydration is your main concern)

What are Rejuran treatments for?

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Results can be seen as early as the first two weeks, however it takes 3-6 months for maximal collagen remodelling to occur.
 

A series of 2-4 sessions, spaced 2-4 weeks apart is recommended for the best results.

How long do results take to see after Rejuran treatments?

How many Rejuran treatments do I need?

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Three Rejuran sessions are recommended, every 2-4 weeks.

 

If you have more obvious skin concerns such as peri-menopausal skin changes ,sun damage, crepey/thin skin or sensitivity, a 4th treatment is strongly recommended.
 

After the initial protocol of 3 or 4 sessions, 1-2 sessions are recommended every year to maintain the effects.

Are there any contraindications to Rejuran?

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The only known complication of using Rejuran is when treating the same layer of the skin that has already had cross-linked fillers injected into it. This can rarely result is 'nodules' - firm lumps that can be troublesome to treat and may be unsightly. Cross-linked fillers are sometime known as 'skin boosters' and so to be safe, please find out from your previous injector what filler was used and where to avoid this rare issue.

Can Rejuran cause vascular occlusions or blindness like fillers?

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Rejuran has been used for 10 years in South Korea and other countries. To date, over 10 million syringes have been used and not a single case of vascular occlusion or blindness has been reported. Rejuran is made from completely different ingredients to dermal fillers and so this is thought to be the reason why the risk has so far been shown to be zero when using Rejuran.

Rejuran Treatment Areas

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Eyes    Face    Neck    Decolletage 

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